Monday, January 16, 2017

(LML) Infolep monthly overview of new publications on leprosy - January 2017

Leprosy Mailing List – January 16,  2017

Ref.: (LML) Infolep monthly overview of new publications on leprosy - January 2017

From:  Jiske Erlings, Amsterdam, the Netherlands


Dear Pieter and LML readers,

Dear friends and colleagues, 
Happy New Year and welcome to the first Infolep mailing of 2017.
2016 has been a productive year for Infolep leprosy information services:

  • The Infolep portal now offers access to over 26,200 publications (800 items added in 2016);
  • The portal received 33,512 unique visitors (versus 29,348 in 2015, +14%);
  • Development of a new look & improved search functionality for the portal;
  • Implementation of French, Portuguese and Spanish interfaces started.

We would like to thank our partners American Leprosy Missions, DAHW, Damien Foundation, Fairmed, Fontilles, Fondation Raoul Follereau, Lepra, Leprosy Relief Canada and NLR for their continued support. With their help we can continue to strive for the best possible leprosy information services in 2017!

Below you will find a selection of recent publications on leprosy. Feel free to contact me ( to receive the full text versions if a link to the full text is not included. Please send us your publications on leprosy or material on leprosy in your language to include in the portal.

With kind regards,
Jiske Erlings
Infolep Information specialist



Highlighted publications



WHO Global Leprosy Strategy 2016-2020.
EnglishFrançais - Español - Portugués 

WHO Global leprosy strategy 2016-2020 - Operational Manual. 
English - Français

International textbook of leprosy.
Scollard DM, Gillis TP. American Leprosy Missions. 2016.

Now online - with new chapters!



New publications



HLA Alleles are Genetic Markers for Susceptibility and Resistance towards Leprosy in a Mexican Mestizo Population.
Aguilar-Medina M, Escamilla-Tilch M, Frías-Castro LO, et al. Ann Hum Genet. 2016 Dec 27.
Read abstract 

Evaluation of Teaching on Leprosy by Students at a Brazilian Public Medical School.
Alves CRP, Araujo MG,  Ribeiro MMF et al. Rev. bras. educ. med. 2016; 40 (3).3.
Download PDF

Non-exponential growth of Mycobacterium leprae Thai-53 strain cultured in vitro.
Amako K, Iida KI, Saito M, et al. Microbiol Immunol. 2016 Dec 7.
Read abstract

Number of leprosy reactions during treatment: clinical correlations and laboratory diagnosis.
Antunes DE, Ferreira GP, Nicchio MV, et al. Rev Soc Bras Med Trop. 2016 Nov-Dec;49(6):741-745.
Download PDF

Binns C, Low WY. Asia Pac J Public Health. 2016 Oct;28(7):560-561.
Download PDF

Reducing Stigmatisation of Leprosy: What is Being Done?
Castro CBJM. J Tradi Med Clin Natur. 2016; 5: 194.
Download PDF

Leprosy in a patient infected with HIV.
Galtrey CM, Modarres H, Jaunmuktane Z, et al. Pract
Neurol. 2016 Dec 9.
Read abstract

Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil.
Hungria EM, Oliveira RM, Penna GO, et al. Infect Dis Poverty. 2016 Dec 6;5(1):110.
Download PDF

Conjugal leprosy: is there a need for active surveillance in endemic areas?
Jindal A, Prabhu SS, Shenoi SD, et al. Trop Doct. 2017 Jan 1:49475516686541.
Download PDF

Infectious Granulomatous Dermatitis at a Tertiary Care Centre in North Maharashtra: A Histopathological Study.
Kumbar R, Dravid N, Nagappa KG, et al. J Clin Diagn Res. 2016 Nov;10(11):EC13-EC16.
Download PDF

Diabetes Mellitus, Leprosy: Intensive Education Protocol in Foot at Risk, Santa Marcelina Hospital, Amazon, Brazil.
Leite O, Oliveria V, Rodrigues A, et al. Open Journal of Endocrineand Metabolic Diseases. 2017; 7, 52-58.
Download PDF

The Impact of a Rights-Based Counselling Intervention to Reduce Stigma in People Affected by Leprosy in Indonesia.
Lusli M, Peters R, van Brakel W, et al. PLoS Negl Trop Dis. 2016 Dec 13;10(12):e0005088.
Download PDF

Consider leprosy as an aetiology of sensory neuronopathy.
Mansukhani KA, Khadilkar SV. Muscle Nerve. 2016 Dec 22.
Read abstract

Sociodemographic and epidemiological profile of leprosy patients in an endemic region in Brazil.
Martins RJ, Carloni ME, Moimaz SA, et al. Rev Soc Bras Med Trop. 2016 Nov-Dec;49(6):777-780.
Download PDF

"I Wasted 3 Years, Thinking It's Not a Problem": Patient and Health System Delays in Diagnosis of Leprosy in India: A Mixed-Methods Study.
Muthuvel T, Govindarajulu S, Isaakidis P, et al. PLoS Negl Trop Dis. 2017 Jan 12;11(1):e0005192.
Download PDF

Ultrasound elastography assessment of the median nerve in leprosy patients.
Nogueira-Barbosa MH, Lugão HB, Gregio-Júnior E, et al.Muscle Nerve. 2016 Dec 15.
Read abstract

Global leprosy strategy 2016-2020: Issues and concerns.
Rao PN. Indian J Dermatol Venereol Leprol. 2017 Jan-Feb;83(1):4-6.
Download PDF

Leprosy and bone marrow involvement.
Rastogi P, Chhabria BA, Sreedharanunni S, et al.QJM. 2016 Nov 15. pii: hcw204.
Download PDF

Unusual Presentation of Multibacillary Nodular Leprosy.
Raut S, Kanade S, Nataraj G, et al. J Lab Physicians. 2017 Jan-Mar;9(1):57-59.
Download PDF

Evaluation of Polymerase Chain Reaction (PCR) with Slit Skin Smear Examination (SSS) to Confirm Clinical Diagnosis of Leprosy in Eastern Nepal.
Siwakoti S, Rai K, Bhattarai NR, Agarwal S, et al. PLoS Negl Trop Dis. 2016 Dec 27;10(12):e0005220.
Download PDF

Autophagy Is an Innate Mechanism Associated with Leprosy Polarization.
Silva BJ, Barbosa MG, Andrade PR, et al. PLoS Pathog. 2017 Jan 5;13(1):e1006103.
Download PDF

Type 1 reaction in leprosy patients corresponds with a decrease in pro-resolving and an increase in pro-inflammatory lipid mediators.
Silva CA, Webb K, Andre BG, et al. J Infect Dis. 2016 Dec 8.
Read abstract

Th9 cytokines response and its possible implications in the immunopathogenesis of leprosy.
de Sousa JR, Pagliari C, de Almeida DS, et al. J Clin Pathol. 2016 Dec 7.
Read abstract

Increased IL-35 producing Tregs and CD19(+)IL-35(+) cells are associated with disease progression in leprosy patients.
Tarique M, Saini C, Naqvi RA, et al. Cytokine. 2016 Dec 27;91:82-88.
Read abstract

A large-scale genome-wide association and meta-analysis identified four novel susceptibility loci for leprosy.
Wang Z, Sun Y, Fu X, et al. Nat Commun. 2016 Dec 15;7:13760.
Download PDF



Journals & Newsletters



Community Eye Health Journal:

Disability, CBR & Inclusive Development:

Hansenologia Internationalis:

Indian Journal of Leprosy: 

Leprosy Review:
Leprosy Review Repository (1928-2001) :

Plos Neglected Tropical Diseases:
Revista de Leprología:
WHO Goodwill Ambassador’s Newsletter for the elimination of leprosy: 



Websites & Services



InfoNTD - Information on cross-cutting issues in Neglected Tropical Diseases (NTDs)

LML - Leprosy Mailing List - a free moderated email list that allows all persons interested in this theme to share ideas, information, experiences and questions.



LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link:

Contact: Dr Pieter Schreuder <<



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Saturday, January 14, 2017

(LML) InfoNTD monthly mail with the latest publications on cross-cutting issues and NTDs - January 2017

Leprosy Mailing List – January 15,  2017

Ref.: (LML) InfoNTD monthly mail with the latest publications on cross-cutting issues and NTDs - January 2017

From:  Ilse Egers & Evelien Dijkkamp, Amsterdam, the Netherlands


Dear Pieter and LML readers,

Happy New Year from InfoNTD!

2016 has been a productive year for InfoNTD!

  • The portal now offers easy access to more than 2200 publications (of which ~1660 open access).
  • We have made a start with the French, Portuguese and Spanish interfaces.

This newsletter provides you with a selection of news items and recent publications on cross-cutting issues in NTDs. Our starting point is to add articles covering a wide variety of issues. Unfortunately, this is not always possible due to a limited diversity in and shortage of articles on cross-cutting issues and NTDs.

Feel free to contact us ( with any questions or to receive the full text versions if a link to the full text is not included. Our document delivery service is free!

Kind regards,
Ilse Egers & Evelien Dijkkamp
InfoNTD Information officers






Tackling neglected tropical diseases through human security - The Lancet Global Health Blog
Fall down seven times, stand up eight.” This Japanese proverb encapsulates the many challenges on the road to achieving human security for all—life without want, without fear, and in dignity through the fulfilment of basic needs—and emphasizes the need for creativity, flexibility, and constant innovation to achieve this broad-ranging mandate.
Read more

Volunteers with no medical training are fighting diseases the world ignores - The Huffington Post
Ordinary people, without any formal medical training, have stepped up to teach others about common illnesses in the province of Nampula, Mozambique, which has one of the highest rates of neglected tropical diseases in the country ― but where many people live in remote, rural communities, far from any health centers.
Read more



New publications



Stigmata in cutaneous leishmaniasis: Historical and new evidence-based concepts.
Al-Kamel MA. PLoS Negl Trop Dis. 2016; 10(12):e0005261.
Abstract The author highlights historical and current concepts of cutaneous leishmaniasis (CL) as a globally most prevalent and highly stigmatizing form of leishmaniasis disease, introduce new ideologies upon CL-related stigmata, review the most common determinants and implications of CL stigmata; and report a short survey illustrating stigmata experience among some affected patients from Yemen.
Download PDF

Former Buruli ulcer patients' experiences and wishes may serve as a guide to further improve Buruli ulcer management.
Velink A, Woolley RJ, Phillips RO, Abass KM et al. PLoS Negl Trop Dis. 2016; 10(12):e0005261.
Abstract To get insight into patient perception of the management and control of Buruli ulcer a mixed methods research design was applied with a questionnaire and focus group discussions among former BU patients. Former patients positively evaluated both the effectiveness of the treatment and the financial contribution received for the travel costs to the hospitals. Pain experienced during treatment procedures, in particular wound care and the streptomycin injections, and the side-effects of the treatment were negatively evaluated.
Download PDF

Neglected diseases: How intellectual property can incentivize new treatment.
Banthia V. Chicago-Kent Journal of Intellectual Property. 2016;16(1).
Abstract This paper addresses the imbalance in the development of treatments for neglected diseases. It analyzes the causes behind the imbalances, and the current legal and societal initiatives that are in place to address the diseases. In particular, the paper suggests that the current patent system fails to effectively incentivize the development of treatment for neglected diseases.
Download PDF

Towards control of Chagas disease: the contribution of the new Brazilian consensus.
Ramos AN, Dias JCP, Correia D. Rev Soc Bras Med Trop. 2016; 49 Suppl 1:1-2.
Abstract On behalf of the Brazilian Society of Tropical Medicine (BSTM), we present the Second Brazilian Consensus on Chagas Disease, which was developed through intense collaboration among Brazilian experts specialize in different aspects of the disease.
Download PDF

Can India succeed in eliminating Kala-azar in near future?
Kumari S, Kishjore J. Epidemiology International. 2016; 1(3):3-9.
Abstract This study aimed to assess progress towards elimination of visceral leishmaniasis from India and to identify major challenges in the path of its elimination and to suggest remedial measures to be undertaken to achieve the goal in future. Conclusions included that Kala-azar is very difficult to be eradicated till strategic modifications are not made. Indoor residual spray should be supervised strictly. There is a need for drug compliance and omitting irregular and incomplete treatment.
Download PDF

Diagnostic tests to support late-stage control programs for schistosomiasis and soil-transmitted helminthiases.
Hawkins KR, Cantera JL, Storey HL et al. PLoS Negl Trop Dis. 2016; 10(12):e0004985.
Abstract There has been increasing recognition within the schistosomiasis and STH communities of the need for improved diagnostic tools to support late-stage control program decisions, such as when to stop or reduce MDA. Based on this analysis, there is a need to develop antigen-detecting rapid diagnostic tests (RDTs) with simplified, field-deployable sample preparation for schistosomiasis. Additionally, there is a need for diagnostic tests that are more sensitive than the current methods for STH, which may include either a field-deployable molecular test or a simple, low-cost, rapid antigen-detecting test.
Download PDF

Mapping soil transmitted helminths and schistosomiasis under uncertainty: A systematic review and critical appraisal of evidence.
Araujo Navas AL, Hamm NAS et al. PLoS Negl Trop Dis. 2016; 10(12):e0005208.
Abstract Using currently published literature on the spatial epidemiology of helminth infections we identified: (1) the main uncertainty sources, their definition and quantification and (2) how uncertainty is informative for STH programme managers and scientists working in this domain.
Download PDF

Infection with Schistosoma mansoni has an effect on quality of life, but not on physical fitness in schoolchildren in Mwanza Region, North-Western Tanzania: A cross-sectional study.
Kinung'hi S, Magnussen P, Kaatano G, Olsen A. PLoS Negl Trop Dis. 2016; 10(12):e0005257.
Abstract Of the measured morbidity parameters, S. mansoni infection had a significant effect on the emotional dimension of quality of life, but not on physical fitness. If PedsQL should be a useful tool to measure schistosome related morbidity, more in depth studies are needed in order to refine the tool so it focuses more on aspects of quality of life that may be affected by schistosome infections.
Download PDF

Differential effect of mass deworming and targeted deworming for soil-transmitted helminth control in children: a systematic review and meta-analysis.
Clarke NE, Clements ACA, Doi SA, Wang D, Campbell SJ, Gray D, Nery SV. Lancet. 2016.
Abstract We aimed to do a systematic review and meta-analysis to compare the effect of mass (community-wide) and targeted (children only) anthelmintic delivery strategies on soil-transmitted helminth prevalence in school-aged children. The results of this meta-analysis suggest that expanding deworming programmes community-wide is likely to reduce the prevalence of soil-transmitted helminths in the high-risk group of school-aged children, which could lead to improved morbidity outcomes.
Download PDF

The impact of lymphatic filariasis mass drug administration scaling down on soil-transmitted helminth control in school-age children. Present situation and expected impact from 2016 to 2020.
Mupfasoni D, Montresor A, Mikhailov A, King J. PLoS Negl Trop Dis. 2016; 10(12):e0005202.
Abstract Eighty percent of all co-endemic countries that have already stopped LF MDA nationally were able to establish STH PC through schools. It is estimated that 14% of the total number of children presently covered by the LF programme is at risk of not continuing to receive PC for STH. In order to achieve and maintain the WHO 2020 goal for STH control, there is an urgent need to establish and reinforce school-based deworming programmes in countries scaling-down national LF elimination programmes.
Download PDF

Zika virus: Promoting male involvement in the health of women and families.
Osamor PE, Grady C. PLoS Negl Trop Dis. 2016; 10(12):e0005127.
Abstract Recent heightened media and public health attention to Zika virus (ZIKV) infection has focused on mosquito control, risks to pregnant women, and controversy over the summer Olympics. Missing from these messages is an emphasis on the essential role of men in decisions and behaviors related to ZIKV transmission and outcomes. It is our thesis that the role of men encompasses more than strategies to reduce risk of sexual transmission.
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Investment success in public health: An analysis of the cost-effectiveness and cost-benefit of the Global Programme to Eliminate Lymphatic Filariasis.
Turner HC, Bettis AA, Chu BK et al. Clin. Infect. Dis. 2016.
Abstract The projected cost-effectiveness and cost-benefit of preventive chemotherapy were very promising and this was robust over a very wide range of costs and assumptions. When not including the economic value of the donated drugs, the GPELF would be classed as highly cost-effective.
Download PDF

Financial burden of health care for Buruli ulcer patients in Nigeria: the patients' perspective.
Chukwu JN, Meka AO, Nwafor CC et al. Int Health. 2016.
Abstract This study assessed the costs of Buruli ulcer care to patients from the onset of illness to diagnosis and to the end of treatment. The median (IQR) direct medical and non-medical cost per patient was US$124 (50-282) and US$3 (3-6); corresponding to 149% and 4% of the patients' median monthly household income, respectively. Direct costs of Buruli ulcer diagnosis and treatment are catastrophic to a substantial proportion of patients and their families.
Download PDF

Benchmarking the cost per person of mass treatment for selected neglected tropical diseases: An approach based on literature review and meta-regression with web-based software application.
Fitzpatrick C, Fleming FM, Madin-Warburton M et al. PLoS Negl Trop Dis. 2016; 10(12):e0005037.
Abstract The available evidence confirms that mass treatment offers a low cost public health intervention on the path towards universal health coverage. However, more costing studies focussed on elimination are needed. Unit cost benchmarks can help in monitoring value for money in programme plans, budgets and accounts, or in setting a reasonable pay-out for results-based financing mechanisms.
Download PDF

Spatial distribution of lymphatic filariasis in Cross River state, Nigeria: a geographical information systems (gis) study.
Ukpong I, Davison Mbere-obong J. International Journal of Research – Granthaalayah. 2016; 4(12):101-109.
Abstract This study was aimed at mapping and describing the transmission pattern of lymphatic filariasis in order to identify high risk zones of infection in Cross River State (CRS), to guide intervention programmes. The study has produced prevalence map of LF in the state, which could guide intervention programmes; and has also revealed paucity of data at the disposal of healthcare authorities, a situation that could hinder large scale intervention.
Download PDF






5th Anniversary of the London Declaration on NTDs
January 30, 2017
A lot has been achieved in 5 years since the World Health Organization roadmap on NTDs was launched and the London Declaration on NTDs signed.  
Read more

ISNTD Festival
February 23, 2017, London, UK
The International Society for Neglected Tropical Diseases
This unique event is bringing together the creative & communications industries with the field of tropical diseases. We have a global call for some of the best content in media & communication.
Read more

LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link:

Contact: Dr Pieter Schreuder <<

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(LML) Indian Leprosy Vaccine

Leprosy Mailing List – January 15,  2017

Ref.:  (LML) Indian Leprosy Vaccine 

From:  Eric Wan, Maryland, USA


Dear Dr. Schreuder and LML,


I recently read on the news about a vaccine trial on-going in India. I recall Dr. Grace Warren's September 18 2016 LML post in which she inquired for more information. I am a young researcher fairly new to the field and would like to learn more about the history and science of this vaccine. Will anyone be able to help give a complete timeline and bibliography / references? 


In my pursuit of knowledge, I asked the United States Food and Drug Administration but they and our National Cancer Institute told me they don't have any information on the vaccine marketed as mycobacterium pranii (MiP) or IMMUVAC. They only have information on approved drugs, so perhaps it's in the works?



Many thanks,





Eric Lee Wan, BS

Consultant (Community Health & Research)
Fundación Padre Damian
Guayaquil, Ecuador
+593 4-228-6649

Research Affiliate
Department of Plastic and Reconstructive Surgery,
Johns Hopkins University School of Medicine
Baltimore, Maryland, USA

Google Voice: +1 (678) 744-9361
USA Cell: +1 (240) 899-1181
Ecuador Cell: +593 (96) 804-5383
Colombia Cell: +57 (313) 780-6653
Skype: ericleewan

LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link:

Contact: Dr Pieter Schreuder <<

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Friday, January 13, 2017

(LML) Silent neuritis. Nerve damage. Disability and deformity. Prevention and management.


Leprosy Mailing List – January 13,  2017

Ref.:   (LML) Silent neuritis. Nerve damage. Disability and deformity. Prevention and management.

From:  Jannine Ebenso, Middlesex, UK

Dear Pieter,


Thank Dr. Francesca for her input into this fascinating dicussion. (LML, January 7, 2017)

Although no longer on the field, during  my 16 years managing leprosy and reaction in Nigeria, I never had access to monofilaments, so always carried my ballpoint pens everywhere with me.

Thanks for reminding us of the basics of monitoring nerve function. Being from Lancashire (UK folk will understand), I seek to be  practical and like to ensure that what we recommend is actually feasible on the field.

With that in mind, you have stated that “The importance of Nerve Function Assessment during the first visit and monthly till completion of treatment or every two weeks should there be an impairment noted must be recorded. Thereafter, yearly evaluation for three years among PB cases and for five years among MB cases should be a part of the Posttreatment Standard to determine leprosy complications particularly leprosy reactions including examination of household contacts. Most of the time, the latter, is no longer considered.”

The Nigerian programme is managed by the government supported by ILEP members. Although we were successful in ensuring monthly nerve function assessment (NFA) during MDT, to my knowledge we never achieved the annual NFA post-treatment. The exception would be among members of self-care groups

I would be very interested to hear from Philippines and other countries how they have managed to achieve this. We can learn from one another’s success stories.


Warm regards



Jannine Ebenso

Head of Quality Assurance

The Leprosy Mission International, 80 Windmill Road, Brentford, Middlesex, TW8 0QH

T: +44 (0)208 326 6767  M: +44 (0)7879647895  E:  S: jannine.ebenso2008 W:

P  Please consider the environment before printing this e-mail

LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link:

Contact: Dr Pieter Schreuder <<

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