Tuesday, November 9, 2010

Rifampicin, ofloxacin and minocycline (ROM) in leprosy

Leprosy Mailing List – November 3rd, 2010

Ref.:   Rifampicin, ofloxacin and minocycline (ROM) in leprosy
From: Frankel Richard I., Hawai'i, USA  



Dear Salvatore and Dr Ahmad,

I refer to Dr Ahmad’s message dated LML Nov. 2nd, 2010. Three pertinent references are:

Single-Lesion Multicentre Trial Group.  Efficacy of single-dose multidrug therapy for the treatment of single-lesion paucibacillary leprosy.  Indian J. Lepr69:121-129 (1997)

Revankar, C.R., Bulchand, H.O., Pai, V.V., et al.  Relapse rate in paucibacillary leprosy treated with single dose.  Int. J. Lepr69:S131 (2001)

Lockwood, D. N. J. Rifampicin/Minocycline and ofloxacin for single lesions—what is the evidence? Lepr Rev 68:299-300 (1997)

This treatment is discussed briefly in the chapter on Leprosy by Dr. Scollard and myself in the Fourth Edition of "Bacterial Infections of Humans", edited by Drs. Brachman and Abrutyn, published by Springer in 2009.

Sincerely,

Richard I. Frankel, M.D., M.P.H., F.A.C.P.
Emeritus Professor of Medicine
University of Hawai'i

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